PLATELETS AND THROMBOPOIESIS Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression
نویسندگان
چکیده
1Department of Anesthesiology and Critical Care Medicine, and 2The GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; 3National Heart, Lung, and Blood Institute’s (NHLBI) Framingham Heart Study, Framingham, MA; 4Division of Intramural Research, NHLBI, Bethesda, MD; 5Department of Neurology, Boston University School of Medicine, Boston, MA; 6Department of Biostatistics, Boston University School of Public Health, Boston, MA; 7Royal North Shore Hospital, University of Sydney, Sydney, Australia; 8Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; 9Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD; 10Population Genetics, deCODE Genetics, Reykjavik, Iceland; 11Division of Hematology, Department of Medicine, Thomas Jefferson School of Medicine, Philadelphia, PA; and 12Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
منابع مشابه
PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.
Platelet endothelial aggregation receptor-1 (PEAR1) participates in platelet aggregation via sustaining αIIbβ3 activation. To investigate the role of PEAR1 in platelet formation, we monitored and manipulated PEAR1 expression in vitro in differentiating human CD34(+) hematopoietic stem cells and in vivo in zebrafish embryos. PEAR1 expression rose during CD34(+) cell differentiation up to megakar...
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Platelet endothelial aggregation receptor-1 (PEAR1) is a type-1 membrane protein with an EMI domain (characteristic for EMILIN protein family), epidermal growth factor-like repeats, and multiple cytoplasmic tyrosines and prolines. We recently reported that interactions between PEAR1, Src family kinases (C-src and Fyn), and the p85/phosphatidylinositol 3-kinase 3-kinase (PI3K) subunit constitute...
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